Ian M Orme Selected Research

Aerosols

1/2018	Biology of clinical strains of Mycobacterium tuberculosis with varying levels of transmission.
1/2015	The Efficacy of the BCG Vaccine against Newly Emerging Clinical Strains of Mycobacterium tuberculosis.
12/2014	Whole genome response in guinea pigs infected with the high virulence strain Mycobacterium tuberculosis TT372.
12/2013	Characterization of W-Beijing isolates of Mycobacterium tuberculosis from the Western Cape.
9/2011	Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells.
6/2011	Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis.
5/2011	Cigarette smoke increases susceptibility to tuberculosis--evidence from in vivo and in vitro models.
3/2011	Comparative studies evaluating mouse models used for efficacy testing of experimental drugs against Mycobacterium tuberculosis.
1/2011	Immune Responses of HIV-1 Tat Transgenic Mice to Mycobacterium Tuberculosis W-Beijing SA161.
5/2009	Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs.

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Ian M Orme Research Topics

Disease

70	Tuberculosis (Tuberculoses) 01/2018 - 10/2002
60	Infections 01/2018 - 02/2002
13	Granuloma 02/2012 - 03/2002
7	Pulmonary Tuberculosis 08/2007 - 03/2002
6	Necrosis 01/2012 - 04/2003
5	Chronic Disease (Chronic Diseases) 11/2007 - 10/2002
4	Pneumonia (Pneumonitis) 07/2010 - 08/2005
3	Inflammation (Inflammations) 04/2014 - 11/2008
3	Body Weight (Weight, Body) 11/2008 - 06/2005
3	Latent Tuberculosis 05/2007 - 04/2003
2	Lung Diseases (Lung Disease) 07/2010 - 03/2005
1	Type 2 Diabetes Mellitus (MODY) 04/2014
1	Reinfection 05/2012
1	Lymphangitis 05/2010
1	Fibrosis (Cirrhosis) 08/2009
1	Persistent Infection 05/2009
1	Hypoxia (Hypoxemia) 05/2009
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 02/2008
1	Acquired Immunodeficiency Syndrome (AIDS) 02/2007
1	Vasculitis (Vasculitides) 09/2006
1	Lymphadenitis (Adenitis) 09/2006
1	Disease Progression 01/2006

Drug/Important Bio-Agent (IBA)

32	AerosolsIBA 01/2018 - 03/2002
28	VaccinesIBA 12/2017 - 04/2003
12	Pharmaceutical PreparationsIBA 04/2014 - 01/2005
11	CytokinesIBA 01/2016 - 12/2002
7	ChemokinesIBA 01/2016 - 08/2003
7	Proteins (Proteins, Gene)FDA Link 03/2009 - 11/2002
6	Interleukin-10 (Interleukin 10)IBA 04/2014 - 12/2002
5	BCG Vaccine FDA Link 09/2014 - 01/2006
5	DNA (Deoxyribonucleic Acid)IBA 04/2014 - 04/2003
5	Rifampin (Rifampicin)FDA LinkGeneric 02/2012 - 06/2005
5	AntigensIBA 04/2010 - 02/2002
5	Interferon-gamma (Interferon, gamma)IBA 10/2006 - 02/2002
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2014 - 04/2006
4	Isoniazid (Ftivazide)FDA LinkGeneric 02/2012 - 06/2005
4	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2009 - 06/2005
3	Tuberculosis VaccinesIBA 02/2012 - 02/2003
3	Pyrazinamide FDA LinkGeneric 03/2011 - 08/2005
3	Moxifloxacin (Avelox)FDA Link 03/2011 - 06/2005
2	EnzymesIBA 12/2014 - 08/2005
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 04/2014 - 08/2003
2	AntioxidantsIBA 01/2012 - 01/2011
2	Malondialdehyde (Propanedial)IBA 01/2012 - 01/2011
2	Tuberculin (PPD)IBA 07/2011 - 06/2005
2	bedaquiline (R207910)IBA 01/2011 - 09/2007
2	AcidsIBA 05/2010 - 09/2007
2	lymphotactinIBA 08/2009 - 11/2007
2	Subunit VaccinesIBA 01/2009 - 06/2004
2	PolyproteinsIBA 09/2005 - 06/2004
2	Recombinant ProteinsIBA 06/2005 - 06/2004
2	OvalbuminIBA 07/2004 - 11/2002
2	IntegrinsIBA 10/2002 - 07/2002
1	Nitrate ReductaseIBA 02/2015
1	Peptide Hydrolases (Proteases)FDA Link 12/2014
1	Endothelin-Converting EnzymesIBA 12/2014
1	Endothelins (Endothelin)IBA 12/2014
1	InterferonsIBA 04/2014
1	Interleukin-17 (Interleukin 17)IBA 04/2014
1	CarbohydratesIBA 04/2014
1	Interleukin-8 (Interleukin 8)IBA 04/2014
1	Culture MediaIBA 04/2014
1	Glucose (Dextrose)FDA LinkGeneric 04/2014
1	Streptozocin (Streptozotocin)FDA Link 04/2014
1	oxidized low density lipoproteinIBA 01/2012
1	Scavenger Receptors (Scavenger Receptor)IBA 01/2012
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2012
1	Messenger RNA (mRNA)IBA 09/2011
1	Biomarkers (Surrogate Marker)IBA 07/2011
1	Biological ProductsIBA 05/2011
1	SmokeIBA 05/2011
1	Drug CombinationsIBA 03/2011
1	Cysteine (L-Cysteine)FDA Link 01/2011
1	Glutathione (Reduced Glutathione)IBA 01/2011
1	Oxidants (Oxidizing Agents)IBA 01/2011
1	Toll-Like Receptor 2IBA 10/2010
1	LeptinIBA 10/2010
1	dectin 1IBA 10/2010
1	Butylated Hydroxytoluene (BHT)IBA 07/2010
1	Interleukin-4 (Interleukin 4)IBA 07/2010
1	ArginaseIBA 07/2010
1	Small Interfering RNA (siRNA)IBA 08/2009
1	Adenosine Triphosphate (ATP)IBA 05/2009
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 05/2009
1	Metronidazole (Metric)FDA LinkGeneric 11/2008
1	Macrophage Colony-Stimulating FactorIBA 04/2008
1	ApoferritinsIBA 01/2008
1	Transferrin Receptors (Transferrin Receptor)IBA 01/2008
1	Iron-Binding ProteinsIBA 01/2008
1	LactoferrinIBA 01/2008
1	IronIBA 01/2008
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 11/2006
1	Matrix Metalloproteinases (MMPs)IBA 11/2006
1	ElementsIBA 09/2006
1	Nanoparticle Drug Delivery SystemIBA 10/2005

Therapy/Procedure

11	Drug Therapy (Chemotherapy) 01/2018 - 01/2004
3	Therapeutics 01/2011 - 06/2005
1	Combination Drug Therapy (Combination Chemotherapy) 02/2012
1	Injections 01/2006